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Capabilities and Technologies

GFS Chemicals is a full service partner and specialty chemical manufacturer in the development of reagents and catalysts that you need in order to fully leverage your chemical development and processing operations. We are capable of supporting businesses on bulk/pilot/research scales.

GFS has become the leader in the development and production with the widest range of acetylenic, olefinic and silyl intermediates.  GFS is the dominant manufacturer, offering over 2/3 of the 600 acetylenic compounds available today. That is over twice the number offered by any other supplier.

We offer an extensive line of silyl-intermediates, triflates, and many other core organic products available in research or bulk.

Our staff has decades of technical expertise in acetylene, olefin, Grignard, and liquid ammonia chemistries.

Total GFS manufacturing capacity exceeds 100,000 liters for the combined production of specialty chemicals. GFS is ISO-9001:2008 certified.

The heart of our organic chemical manufacturing is a 14,000 square foot, indoor, state-of-the-art product facility in Columbus, Ohio - open since 2000. This new chemical plant demonstrates GFS Chemicals' investment to specialty organic chemicals.


Batch Unit Operations
Batch unit operations include: batch reactions; non-reactive mixing; extraction; filtration; centrifugation; crystallization and drying (tray and rotary vacuum); distillation and stripping; and sublimation (kilo lab scale).


Bulk Chemical Handling
We are capable of handling these bulk chemicals: anhydrous liquid ammonia; destabilized acetylene; sodium/lithium and corresponding amides; bromine; iodine; ethylene oxide; thionyl chloride; sulfuryl chloride; chlorosulfonic acid; hydrogen sulfide; sodium cyanide; liquid nitrogen; carbon disulfide trimethylchlorosilane and organosilanes.


Core Competencies

  1. Acetylene chemistry
  2. Propargylic amines
  3. Custom Grignard chemistry
  4. Specialty halides
  5. Si blocked compounds
  6. Birch reductions
  7. Alpha/omega functionalization
  8. Bromine Chemistry


Unit Operations Supported

  1. Distillation
    1. Stripping
    2. Rectification
    3. Wiped film distillation
    4. Atmospheric pressure to ~ 1 mm Hg vacuum
  2. Crystallization
  3. Centrifugation
  4. Filtration
  5. Extraction
  6. Drying (vacuum to atmospheric)
    1. Rotary
    2. Tray

Core Organic Product Lines

  1. Alkynes
    1. Terminal & internal bond positions
    2. Diynoic acids, alkynols, halo-alkynes
  2. Specialty olefins
    1. Dienes, ene-ynes, α,ω halo-olefins
    2. Pure cis and trans isomers
  3. Insect pheromones
  4. Grignard reagents
  5. Specialty halides
    1. Bromides
    2. Chlorides
    3. Iodides
    4. Halo-hydrins
  6. Bipyridines & phenanthrolines
  7. Phenanthrolines
  8. Terpyridines

Organic Reaction Expertise

  1. Acetylide coupling
  2. Alkylation
  3. Amidation
  4. Amination
  5. Birch Reduction
  6. Bromination
  7. Chlorination
  8. Dehydrohalogenation
  9. Dissolving metal reductions (Li, Na)
  10. Friedel-Crafts reaction
  11. Gabriel synthesis
  12. Grignard (preparation and use)
  13. Iodination
  14. Low P hydrogenation
  15. Skraup reaction
  16. Sonogashira coupling
  17. Stille coupling
  18. Suzuki coupling

New Technologies

  1. Thiophenes
  2. Bridged orthoesters

Hazardous Materials Handled

  1. Acetylene
  2. Acrolein
  3. Allyl halides
  4. Ammonia (liquid)
  5. Bromine
  6. Butyllithium
  7. Carbon disulphide
  8. Chloroformates
  9. Chlorosulfonic acid
  10. Epichlorohydrin
  11. Ethylene oxide
  12. Hydrogen bromide
  13. Hydrogen chloride
  14. Iodine
  15. Lithium
  16. Lithium amide
  17. Methyl bromide
  18. Methyl iodide
  19. Organolithium compounds
  20. Red phosphorus
  21. Phosphorous halides
  22. Sodamide
  23. Sodium
  24. Sulphur dioxide
  25. Thionyl chloride